Table 3.

Diagnostic accuracy of DAPHNE and of the Rascovsky’s revised clinical criteria to differentiate FTD and fAD patients

	Threshold	Sensitivity	Specificity	Positive likelihood ratio
Rascovsky’s clinical criteria	≥3	100%	25%	1.3
DAPHNE-6	≥4	92%	55%	2.0
DAPHNE-40	≥16	47%	85%	3.1
DAPHNE ‘combined’	-	92%	85%	6.1

fAD, frontal Alzheimer’s disease; FTD, behavioral variant frontotemporal dementia. The positive likelihood ratio is assumed to demonstrate the interest of a diagnostic tool when >5. Thus, the value > 5 is shown in bold.