Fig.1.

Relationship of age at motor onset with CAG repeat. A. Age at onset of motor signs estimated by raters (Y-axis) is compared to the size of uninterrupted CAG repeat (X-axis) for subjects with inherited CAG sizes of 40–55 repeats. Each circle represents a HD subject participating our recent onset modifier GWA study [37]. B. Age at onset of motor signs for the subset of HD subjects who inherited 43 CAGs (∼15.5% of the total data set) is plotted to show the wide variability in clinical manifestation due to factors other than CAG repeat length.