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. 2021 Feb 24;5(1):111–120. doi: 10.3233/ADR-200246

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© 2021 – The authors. Published by IOS Press

This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 2 — Rates of change in cognitively normal adults stratified by amyloid-β status, APOE ɛ4 interaction. Rates of change are presented for (a, d) global cognition (SD/year), (b, e) verbal episodic memory (SD/year) and (c, f) AIBL-PACC (4×SD/year) in cognitively normal older adults with low (a, b, c; n = 336) or high (d, e, f; n = 254) amyloid-β. APOE ɛ4-ve/SPON1^A– (green), APOE ɛ4-ve/SPON1^A+ (blue), APOE ɛ4 + ve/SPON1^A– (orange), APOE ɛ4 + ve/SPON1^A+ (red). Controlling for age in AIBL-PACC. Error bars represent time dependent standard error. ^*p < 0.05 when comparing to the APOE ɛ4-ve/SPON1^A– carrier group, ^†p < 0.05 when comparing to the APOE ɛ4-ve/SPON1^A+ group, ^‡p < 0.05 when comparing to the APOE ɛ4 + ve/SPON1^A– carrier.