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Biosynthesis of Omega-3 and Omega-6 PUFAs is shown at the center. The oxidative metabolism of LA, DGLA, AA, EPA, and DHA into their respective lipid mediators through oxygenase enzymes is also shown in the right and left sides. COX: cyclooxygenase; LOX: lipoxygenase; MPO: myeloperoxidase [19, 33, 48, 60].
