Figure 5. Administration of luminally acting 5-HT4R agonist enhanced motility in two models of constipation.
A. Pellet output was decreased in aged animals, as compared to younger mice. In aged mice, fecal output was increased by 5HT4-LA1 and by prucalopride. B. Graphs showing paired data from mice tested for whole gut transit, colonic motility and water content at three different time points: Day 0, before induction of EAE, at Day 21–22, when EAE symptoms had developed, and Day 25–26, when EAE symptoms were still present. Changes in intestinal function consistent with constipation were evident at 21–22 days, and they were reversed to normal levels by treatment with 5HT4-LA1. 2-way ANOVA. *p≤0.05; **p≤0.01; ***p≤0.001; ****p≤0.0001.