Figure 6. Luminally acting 5-HT₄R agonist administration enhances contractile activity of isolated colons.

A. Examples of motility patterns (left panels = diameter ST maps, middle panels = Δ diameter ST maps) after vehicle administration and quantified prevalence of contractile activity along the length of the colon (right panel n=4). B. Prior 5-HT₄R agonist administration significantly enhanced the degree of contractile activity in isolated colons, particularly in the distal regions of the preparations, as shown in the summary data (C) and (D) where activity was averaged into proximal (0–40% length) and distal (60–100% length) colonic regions. * p<0.05.