Skip to main content
. Author manuscript; available in PMC: 2022 Mar 3.
Published in final edited form as: Dev Neurosci. 2021 Mar 3;42(5-6):195–207. doi: 10.1159/000513536

Fig. 4.

Fig. 4

Single Cell (sc)RNAseq of control and DPM treated cerebral organoids. A). UMAP of cell expression (each dot) pooled from both control and DPM organoids identifying 19 cell clusters, labeled A-S with manually curated prediction of identifies. B) Comparison of DPM exposed vs control (Ctrl) cerebral organoids plotted as UMAP. Note the Outer radial glia cell clusters (group F) has a reduced number of cells in DPM exposed conditions (red circle). C) Significant genes of the DPM treatment shown as the highest -log10 adjusted Pvalue (y-axis) and the number of cell clusters that have an adjusted Pvalue <0.0001. Top ten genes are labeled in red. ASD SFARI genes are colored cyan. D) The number of significant genes in each cell cluster (x-axis) and the number of ASD genes significantly changed by DPM treatment. E) Top enriched KEGG pathways for genes found in ¾ of the group J, A, L, I.