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. Author manuscript; available in PMC: 2021 Aug 1.
Published in final edited form as: Nat Chem Biol. 2021 Feb 1;17(4):456–464. doi: 10.1038/s41589-020-00725-y

Extended Data Fig. 1. Cdk2 inhibitors drive conformational shifts upon binding.

Extended Data Fig. 1

Aligned crystal structures of Cdk2 bound to dinaciclib and roscovitine (top), and structures of Cdk2:cyclinA bound to flavopiridol and ADP shown side by side (bottom). Hydrogen bonds are shown as yellow dashed lines, and structured water molecules as red spheres. The structure of Cdk2 bound to AZD5438 is shown in Supplementary Fig. 7.