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. Author manuscript; available in PMC: 2021 Aug 1.
Published in final edited form as: Nat Chem Biol. 2021 Feb 1;17(4):456–464. doi: 10.1038/s41589-020-00725-y

Extended Data Fig. 2. A divergent hub controlling allosteric coupling in Cdk2.

Extended Data Fig. 2

a) KM values for phosphorylation of a short peptide substrate (left) and RB (right), measured for WT Cdk2, Cdk2cdk4hub and Cdk4. Values are mean ± S.E.M; n = 4 independent experiments. b) DEER data for the Cdk2cdk4hub mutant bound to cyclinA with and without addition of saturating peptide substrate and AMPPNP.