Extended Figure 2 |. Novelty induces prolonged increases in theta power in the vHPC, but not the dHPC or mPFC.

a, LFP power was measured during and 1 hour after arena exposure, at the onset of Flexible Choice training. b, The novelty-exposed group displayed higher vHPC theta power 1 hour after arena exposure compared with the other groups (Kruskal-Wallis test, P = 0.0007; Novel vs. Familiar: P = 0.001, Novel vs. Control: P = 0.008). c, Theta power in the dHPC was comparable across all groups during (Mann-Whitney test, P = 0.1) and 1 hour after arena exposure (Kruskal-Wallis test, P = 0.4). d, Novelty exposure increased mPFC theta power (Mann-Whitney test, P = 0.002), but this increase was unseen at the onset of Flexible Choice training (Kruskal-Wallis test, P = 0.4). e, A separate cohort of mice explored a T-shaped arena for two consecutive days. f, Theta power in the vHPC decreased in day 2 compared with that of day 1 (Wilcoxon signed-rank test, P = 0.04). g & h, Theta power in the dHPC or mPFC was comparable between day 1 and day 2 (Wilcoxon signed-rank test, g; P = 0.8, h; P = 0.3). Insets, average theta power of each mouse. n.s. not significant. * P < 0.05. ** P < 0.005. Data are represented as mean ± SEM.