Extended Data Fig. 4.

a, Body weights were measured in male MTKO and WT mice housed at 30° C from weaning. All mice were maintained on regular chow. N = 11 WT and 9 MTKO mice. b, Body weights were measured in female MTKO and WT mice housed at 30° C from weaning. All mice were maintained on regular chow. N = 12 WT and 8 MTKO mice. c,d, Gonadal white adipose tissues from 20-week old mice used for data in (a) and (b) were weighed. N=5 WT and 3 MTKO males, and 10 WT and 5 MTKO females. All data are presented as mean ± SEM of biologically independent samples, analyzed using two-tailed t-tests. *p<0.05, **p<0.01, ***p<0.001.