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. 2021 Mar 11;9:570898. doi: 10.3389/fcell.2021.570898

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Copyright © 2021 Shao, Kong, Xu, Wu, Cao, Li, Han, Li, Xie and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The methylation status of OPCML-associated CpG sites in the TCGA dataset. (A) There are only two CpG sites from HumanMethylation27k, and the location of two CpG sites in OPCML. (B) There are significantly positive associations between two CpG sites and OPCML expression. (C) The methylation levels were not significantly associated with clinical stage. (D) The methylation levels were not significantly associated with clinical grade. (E) No significant associations were observed in patient with different methylation levels using log-rank analysis. (F) No significant associations were observed in patient with different methylation levels using cox analysis.