Table 2.
Means for time to EDSS 6 in five subgroups, patients diagnosed before or after 2006 and BT vs. Non-BT patients
| Years to EDSS 6 | 95% CI | Reached EDSS 6 % | p value | |
|---|---|---|---|---|
| BOT-1 | 29.8 | 28.4–31.1 | 34.5 | |
| BT-living | 30.4 | 28.5–32.4 | 31.2 | |
| G1 (diagnosed ≤ 1997) | 26.7 | 25.0–28.5 | 70.5 | < 0.001 |
| G2 (1998–2002) | 25.9 | 23.5–28.3 | 48.5 | |
| G3 (2003–2007) | 31.5 | 28.2–34.8 | 31.3 | |
| G4 (2008–2012) | 36.0 | 31.6–40.4 | 12.7 | |
| G5 (2013–2017) | 42.8 | 36.6–49.1 | 3.7 | |
| Patients diagnosed < 2006 | 27.6 | 26.2–29.0 | 57.8 | < 0.001 |
| Patients diagnosed ≥ 2006 | 35.3 | 32.0–38.6 | 12.3 | |
| BT patients | 27.3 | 25.8–28.9 | 40.4 | < 0.001 |
| Non-BT patients | 33.8 | 31.6–35.9 | 26.7 | |
| Relapsing at onset | 32.2 | 30.7–33.7 | 27.1 | < 0.001 |
| Progressive at onset | 13.9 | 12.1–15.7 | 70.3 | |
| Progressiv at onset | ||||
| G1 (diagnosed ≤ 1997) | 12.0 | 9.6–14.4 | 96.8 | 0.04 |
| G2 (1998–2002) | 10.8 | 8.5–13.1 | 87.9 | |
| G3 (2003–2007) | 11.1 | 8.6–13.6 | 74.3 | |
| G4 (2008–2012) | 19.5 | 14.0–25.0 | 46.3 | |
| G5 (2013–2017) | 17.2 | 11.0–17.0 | 29.6 | |
BOT-1 database of all 2097 patients from Buskerud, Oslo and Telemark included in study, BT-living: geographically complete and living population from Buskerud and Telemark, BT Buskerud and Telemark, Non-BT everyone in BOT-1 who does not reside in Buskerud or Telemark, CI confidence interval