Table 3.

Results from linear mixed-effects regression analyses (unadjusted and adjusted) of EDSS progression over time

Group	Year of diagnosis	Unadjusted			Adjusted
		BOT-1			BOT-1
		(n = 13 075 EDSS)			(n = 12 713 EDSS)
		Coef	95% CI	p value	Coef	95% CI	p value
Age at EDSS		0.144	0.130–0.159	< 0.001	0.148	0.134–0.163	< 0.001
G2	1998–2002	Reference
Diagnostic group
G1	< 1998	1.863	1.028–2.552	< 0.001	1.739	0.912–2.567	< 0.001
G3	2003–2007	0.626	− 0.300–1.552	0.19	0.580	− 0.327–1.487	0.21
G4	2008–2012	2.516	1.607–3.424	< 0.001	2.311	1.415–3.207	< 0.001
G5	2013–2017	3.464	2.371–4.558	< 0.001	2.462	1.372–3.552	< 0.001
Diagnostic group by age of EDSS (interaction term)
G1	< 1998	− 0.02	− 0.036 to − 0.0003	0.05	− 0.021	− 0.040– − 0.003	0.02
G3	2003–2007	− 0.020	− 0.036–0.0004	0.07	− 0.017	− 0.038–0.003	0.09
G4	2008–2012	− 0.072	− 0.092 to − 0.052	< 0.001	− 0.065	− 0.085– − 0.045	< 0.001
G5	2013–2017	− 0.099	− 0.124 to − 0.074	< 0.001	− 0.070	− 0.096– − 0.045	0.001
Intercept		− 3.503	− 4.181 to − 2825	< 0.001	− 1.505	− 2.309–0.701	< 0.001

Adjusted for months spent on all disease-modifying treatment, progressive MS at onset, age at onset and gender. BOT-1: database of all 2097 patients from Buskerud, Oslo and Telemark included in study

Coef regression coefficient, EDSS expanded disability status scale