Table 4.

Comparison of patients in BT and Non-BT patients collectively, as well as before and after 2006

	All patients		p value	< 2006		p value	2006–2017		p value
	BT	Non-BT		BT	Non-BT		BT	Non-BT
	n = 1178	n = 1178		n = 612	n = 440		n = 566	n = 479
Sex ratio (% women), n = 2097	2.0 (66.2)	2.5 (71.6)	0.01	1.9:1 (65.4)	2:5 (71.8)	0.03	2.0:1 (67.1)	2.5:1 (71.4)	0.14
Age at onset, years (SD), n = 2033	35.6 (11.1)	33.2 (10.1)	< 0.001	34.1 (10.3)	31.7 (9.5)	< 0.001	37.2 (11.7)	34.6 (10.5)	< 0.001
Age at diagnosis, years (SD), n = 2097	41.3 (11.6)	38.0 (10.9)	< 0.001	40.4 (10.6)	37.1 (10.0)	< 0.001	42.2 (12.5)	38.8 (11.7)	< 0.001
Onset to diagnosis, years (SD), n = 2033	5.8 (7.2)	4.8 (6.2)	< 0.001	6.6 (7.2)	5.4 (6.2)	0.005	5.0 (7.2)	4.2 (6.2)	0.07
Progressive MS at onset %, n = 1969	12.1	10.3	0.20	13.0	12.5	0.82	11.1	8.4	0.15
≥ 2 relapses before diagnosis %, n = 1716	72.7	65.5	0.001	77.9	73.5	0.17	67.5	61.1	0.04
Onset symptoms %, n = 2001
Visual	18.4	19.6	0.15	22.0	19.4	0.08	14.4	19.6	0.11
Motor	22.3	18.2		24.9	20.8		19.5	16.0
Sensory	34.2	35.0		32.4	33.5		35.9	36.2
Multiple (≥ 2) symptoms at onset %, n = 1645	37.7	25.6	< 0.001	40.7	26.2	< 0.001	33.9	25.1	0.004
Median EDSS at diagnosis (mean), n = 1665	2.5 (2.8)	2.0 (2.4)	< 0.001	3.0 (3.0)	2.5 (2.5)	< 0.001	2.5 (2.6)	2.0 (2.3)	< 0.001
OCB pos %, n = 1935	88.9	91.7	0.05	82.1	88.3	0.02	94.4	94.5	0.92
Patients never treated %, n = 2097	46.9	39.5	0.001	63.2	57.5	0.06	30.2	23.6	0.02
Number of deceased patients (%), n = 2097	175 (14.9)	14 (1.5)	< 0.001	161 (26.3)	13 (3.0)	< 0.001	14 (2.5)	1 (0.2)	0.002

p value: Independent-sample t test for categorical, Chi square for dichotomous

BT Buskerud and Telemark, Non-BT everyone in BOT-1 who does not reside in Buskerud or Telemark, SD standard deviation, EDSS expanded disability status score, OCB pos oligoclonal bands positive