Table 2.
Classification of gonadal function in in a cohort of HIV-infected outpatients with hypogonadal symptoms and complete hormonal profile (Group C, n. 94)
| Group C (n. 94) | Eugonadism | Compensated hypogonadism | Overt hypogonadism | P value |
|---|---|---|---|---|
| Anthropometric parameters | ||||
| n. (%) | 62 (66.0) | 13 (13.8) | 19 (20.2) | / |
| Age (years) | 53.5 (49.0–57.8) | 52.0 (50.0–58.0) | 53.0 (48.5–62.0) | 0.905 |
| BMI (kg/m2) | 25.0 (22.0–27.4) | 25.1 (22.8–26.7) | 26.0 (24.1–28.9) | 0.476 |
| Hormonal parameters | ||||
| TT (ng/ml) | 7.0 (5.7–9.0) | 8.2 (7.0–12.0) | 3.4 (2.5–4.5) | < 0.001 |
| SHBG (nmol/l) | 63.0 (41.8–72.8) | 90.0 (61.9–98.0) | 46.0 (37.0–93.0) | 0.071 |
| cFT (pg/ml) | 106.5 (87.6–124.5) | 89.1 (81.3–120.0) | 53.7 (34.6–61.9) | < 0.001 |
| LH (mUI/ml) | 4.8 (3.0–7.0) | 13.0 (11.0–15.9) | 5.8 (3.6–10.0) | < 0.001 |
| HIV parameters | ||||
| HIV infection (yr) | 11.0 (9.8–20.0) | 25.5 (19.0–28.5) | 11.0 (6.3–16.8) | < 0.050 |
| cART duration (yr) | 8.0 (5.0–17.0) | 17.0 (9.5–23.5) | 9.5 (4–12.8) | 0.084 |
| CD4 nadir (cells/mm3) | 148.0 (57.8–275.0) | 127.0 (89.3–213.8) | 63.0 (25.0–311.0) | 0.798 |
| CD4 nadir (%) | 15.8 (8.1–23.8) | 14.0 (12.0–15.0) | 13.1 (7.5–29.3) | 0.975 |
Categorical variables are presented as number (%). Continuous variables are expressed as median (interquartile range). Overt hypogonadism class comprises primary, secondary and normogonadotropic hypogonadism