Figure 4.

IL-19 deficiency upregulates Th17 cell differentiation–associated cytokines in macrophages. qPCR data for mRNAs encoding IL-1β, IL-6, TGF-β1, IL-12 p40, IL-23 p19, IL-10, and TNF-α in splenic macrophages of untreated (non-immunized) mice or EAE mice. Assessments of the samples from EAE mice were performed 7 days after immunization. Statistical significance was analyzed using one-way ANOVA followed by post-hoc Tukey's test. Data represent means ± SEM. *p < 0.05; ***p < 0.0001 (n = 6). NT, untreated mice.