Table 2.
Performance metrics of individual plasma proteins in addition to clinical covariates for prediction of all-cause mortality in the MDCS-CVA.
| Model | C-statistic | P-value (LR) | IDI | P-value | cNRI | P-value |
|---|---|---|---|---|---|---|
| Clinical model* | 0.7222 | – | – | |||
| + AR | 0.7247 | 0.0001 | 0.0039 | 0.0001 | 0.1673 | < 0.0001 |
| + CXCL9 | 0.7243 | 0.0002 | 0.0033 | 0.0008 | 0.1439 | < 0.0001 |
| + HE4 | 0.7260 | < 0.0001 | 0.0058 | < 0.0001 | 0.1788 | < 0.0001 |
| + GH | 0.7248 | 0.0001 | 0.0042 | 0.0002 | 0.1268 | 0.0006 |
| + GDF15 | 0.7284 | < 0.0001 | 0.0088 | < 0.0001 | 0.1287 | 0.0005 |
| + NTproBNP | 0.7235 | < 0.0001 | 0.0044 | 0.0003 | 0.0569 | 0.1238 |
| + SCF | 0.7253 | < 0.0001 | 0.0057 | 0.0001 | 0.1419 | 0.0001 |
| + UPAR | 0.7266 | < 0.0001 | 0.0040 | 0.0002 | 0.1564 | < 0.0001 |
LR likelihood ratio test, cNRI category-free Net Reclassification Improvement, IDI integrated discrimination improvement.
*Cox regression model including age, sex, smoking status, BMI, educational level, history of hypertension, prevalent diabetes mellitus, C-reactive protein (ln-transformed), HbA1c (ln-transformed), and LDL-cholesterol.