Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Mar 24;11:6722. doi: 10.1038/s41598-021-86209-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Cardiac Mfn1 expression is suppressed in non-responders together with reduction in the size and number of mitochondria in cardiomyocytes. (A) UCG data of responders (Res) and non-responders (Non-Res) at baseline cardiac biopsy (pre) and 7–15 months later (post). LVEF and LV diastolic dimension (LVDd) (n = 14, 14, 8, and 8). (B, C) Transmission EM of cardiac tissue from Res and Non-Res (B), and quantification of the size, area and number of mitochondria per field (n = 10, 8) (C). Scale bar = 2.0 μm. Case 1–5 in Fig. 1B indicates panels are from different individuals. (D) Immunofluorescence for Mfn1 in cardiac tissue from Res and Non-Res. Right panel shows quantification of Mfn1-positive area (n = 12, 5). Scale bar = 50 μm. For this study, an outlier (n = 1 in Res group) and an abnormal value (n = 1 in Non-Res group) were excluded by boxplot (SPSS) for further statistical analysis. (E) Quantitative PCR of cardiac MFN1 expression in Res and Non-Res (n = 13, 8). For this study, an abnormal value (n = 1 in Res) was excluded by boxplot (SPSS) for further statistical analysis. Data were analyzed by two-tailed Student’s t-test. *P < 0.05, **P < 0.01. Results are shown as mean ± SEM. NS not significant. Small circle indicates outlier, triangle indicates abnormal value.