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. 2021 Mar 24;12(4):314. doi: 10.1038/s41419-021-03605-y

Fig. 8. Oleandrin induces breast cancer ER stress.

Fig. 8

A, B MCF7 and MDA-MB-231 cells were treated with oleandrin for 0, 6, 12, and 24 h. The protein expressions were analyzed by western blotting. C MCF7 and MDA-MB-231 cells were pretreated with the PERK inhibitor GSK2606414 at 6 μM and the IRE1 inhibitor 4μ8C at 5 μM for 12 h before treatment with oleandrin for further 6 h. β-actin was used as loading control. D Treated cells were stained with CRT and PI before detected by flow cytometry. The CRT-positive and PI-negative cells were showed in representative dot plots and quantification data. **p < 0.01. ole, oleandrin; GSK, GSK2606414.