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. 2021 Mar 24;11:6785. doi: 10.1038/s41598-021-86176-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Conserved synteny between chickens and humans. The wooden breast QTL-rich region of chicken chromosome 5 (GGA5) has highly conserved synteny with human chromosome 11 (HSA11), especially compared to homologous regions in the mouse genome on chromosomes 2 (MMU2) and 7 (MMU7). In humans, this area is associated with a high number of growth and metabolic disorders, which are highlighted here based on existing knowledge of wooden breast and white striping, including a hypothesis suggesting dysregulation of lipid and glucose metabolism as an important underlying factor in development of the myopathies. The scatter plot on GGA5 represents GWAS results from the present study with significant SNPs in red. Red bands on GGA5 indicate previously identified selective sweeps in commercial purebred broiler lines that are susceptible to wooden breast with overlapping selective sweep regions in dark red. The centromere (pink) and G-banding (grey and white) are shown on HSA11 to improve visualization. Defic: deficiency, ID: insulin-dependent, NID: non-insulin-dependent, PN: permanent neonatal, TN: transient neonatal.