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. 2021 Mar 24;11:6725. doi: 10.1038/s41598-021-86110-8

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Enrichment of neurology/psychiatry drugs in anti-SARS-CoV-2 active compounds. (a) Activity statistics of six common drug classes in the SARS-CoV-2 CPE assay. Class active rate = Fraction of anti-SARS-CoV-2 active compounds in the drug class; Background active rate = Fraction of anti-SARS-CoV-2 active compounds outside the drug class. (b) Distribution of the six common drug classes in the NPC library. (c) Significance of enrichment of anti-SARS-CoV-2 actives in each drug class. Only the class of neurology/psychiatric drugs was significantly enriched. The dotted line indicates the threshold for statistical significance.