Fig. 5.

Mankin score summary and representative histological pictures of cartilage after treatment with IL-1β, T3 or 65% mechanical stress. Cartilage damage was assessed on histology after perturbation with a IL-1β (n = 6), b 65% MS (n = 16/24) or c T3 (n = 22/24). Data are represented as mean ± SEM and each dot represents a single explant. d Representative histological pictures are given of toluidine blue and H&E stainings performed on slides from the different conditions. P values of mean differences between controls and treated explants were estimated by generalized estimating equations (GEE) with robust variance estimators to account for donor effects. *P < 0.05, **P < 0.01