Table 1.
Summary of published series, serology status and kidney biopsy findings in primary Sjögren’s syndrome
| Study | Diagnostic criteria | Total number of patients | Number of patients with kidney biopsy | Serology (of available results) | TIN (percentage of total biopsies) (%) | GN (percentage of total biopsies) (%) |
|---|---|---|---|---|---|---|
| Goules et al. [63] (2000) | European (1993) | 20 | 18 |
ANA 100% Anti-Ro 75% Anti-La 50% RF 75% Low C3 10% Low C4 40% Cryoglobulins 50% |
55 | 40 |
| Bossini et al. [14] (2001) | European (1993) | 60 | 9 |
ANA 85% Anti-Ro 80% Anti-La 40% RF 82% Low C3 8% Low C4 18% Cryoglobulins 13% Hypergammaglobulins 72% |
67 | 33 |
| Ren et al. [8] (2008) | AECG (2002) | 130 | 41 |
Anti-Ro 51% Anti-La 38% RF 58% Low C3 44% Low C4 15% Hypergammaglobulins 71% |
80 | 20 |
| Maripuri et al. [18] (2009) | AECG (2002) | 24 | 24 |
Anti-Ro or anti-La 83% RF 80% Cryoglobulins 13% |
71 | 21 |
| Goules et al. [12] (2013) |
AECG (2002) |
715 | 35 |
Anti-Ro 69% Anti-La 43% RF 63% Low C3 26% Low C4 54% Cryoglobulins 45% Hypergammaglobulins 82% |
37 | 49 |
| Kidder et al. [22] (2015) | n/a | 25 | 25 |
ANA 74% Anti-Ro/La 63% RF 52% Hypergammaglobulins 66% |
48 | 32 |
| Jain et al. [16] (2018) | AECG (2002) | 70 | 17 |
ANA 100% Anti-Ro 97% Anti-La 71% RF 83% Low C3/C4 20% |
24 | 6 |
| Goules et al. [20] (2019) | AECG (2002) | 20 | 12 |
ANA 50% RF 68% Low C3 30% Low C4 55% Cryoglobulins 19% |
59 | 33 |
AECG American-European Consensus Group, GN glomerulopathy, TIN tubulointerstitial nephritis