Figure 1.

Effects of dietary modification on physiologic changes of normal mice. (A) HF diet group gained weight significantly from day 7 after starting the HF diet and showed stationary body weight after switching to a normal diet. The HS diet group had a lower body weight than the control group on day 42 and returned to a body weight comparable with that of the control group 1 week after switching to a normal diet. (B) HF diet significantly increased plasma total cholesterol concentration from day 14 after dietary modification. The total cholesterol level of the HF diet group returned to a comparable concentration after switching to a normal diet. (C) BUN level on day 7 was significantly higher in the HF diet and HS diet groups. Overall renal function measured by plasma creatinine was comparable among groups for the whole study period.*P < 0.05, compared with the control group at each time point. ^†P < 0.05, compared with day 7 in the same group (n = 5 for each group at each time point). Statistical analyses were performed with two-way ANOVA test followed by Tukey's test. HF, high-fat; HS, high-salt; HF+HS, high-fat with high-salt.