Figure 5.

Effects of dietary modification on development of acute kidney injury (AKI) after bilateral IRI surgery. (A,B) The renal functional changes following IRI in each diet group. Deterioration of renal function following IRI tended to be aggravated by HF or a HS diet fed for both 1 week and 6 weeks. BUN and plasma creatinine levels were significantly higher in the HS and HF+HS diet groups fed for 1 week after IRI. Plasma creatinine level in the HF+HS diet group fed for 6 weeks was significantly higher than that of the control group on day 2 after IRI. *P < 0.05, compared with the control group at each time point (n = 5–10 for each group). Statistical analysis was performed using the Mann-Whitney U-test. HF, high-fat; HS, high-salt; HF + HS, high-fat with high-salt.