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. 2021 Mar 11;15:573858. doi: 10.3389/fnins.2021.573858

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Copyright © 2021 Chen, Lv, Wang, Wei, Zhao, Yang, Gong and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Intergroup differences in GMV between tinnitus patients without HL and HCs before and after sound therapy. At baseline, compared with the HCs, the patients with tinnitus without HL exhibited reduced GMV in the left MTG. After sound therapy (treated), the tinnitus patients continued to show decreased GMV in the same region, and the volume of gray matter was further reduced (corrected at the non-stationary cluster level with FWE P < 0.05). HL, hearing loss, HC, healthy control, MTG, middle temporal gyrus, FWE, family wise error, GMV, gray matter volume. The color bar represents the extent of reduction in GMV.