Table 2.
Outcome according to phenotype.
| Characteristics | Total N = 416 | Phenotype 1 N = 150 | Phenotype 2 N = 176 | Phenotype 3 N = 90 | P-valuea | Adjusted p-valueb (1 vs. 2) |
|---|---|---|---|---|---|---|
| Ventilatory mode at day 14, n (%) | ||||||
| - Death - Controlled mode or under VV-ECMO - Pressure Support - Extubated |
93 (22.5) anitha 140 (34.0) anitha87 (21.1) anitha92 (22.3) | 31 (20.8) anitha52 (34.9) anitha31 (20.8) anitha35 (23.5) | 29 (16.8) anitha59 (34.1) anitha43 (24.9) anitha42 (24.3) | 33 (36.7) anitha29 (32.2) anitha13 (14.4) anitha15 (16.7) | 0.02 | > 0.99 |
| Needs for ECMO, n (%) | 49 (11.8) | 14 (9.3) | 30 (17.1) | 5 (5.6) | 0.01 | 0.02 |
| Alive at day 28, n (%) | 273 (66.4) | 101 (67.8) | 124 (72.1) | 48 (53.3) | 0.009 | 0.95 |
| VFD on day 28, median (IQR)anitha N = 407 | 0 (0–13) | 0 (0–13) | 0 (0–14) | 0 (0–8) | 0.03 | >0.99 |
| Breathing without assistance at day 28, n (%) | 173 (42.5) | 68 (45.95) | 79 (46.75) | 26 (28.89) | 0.01 | >0.99 |
| Acute kidney injury, n (%) | 225 (55.1) | 82 (55.41) | 81 (47.65) | 62 (68.89) | 0.005 | 0.41 |
| Need for RRT, n (%) | 78 (19.1) | 32 (21.33) | 27 (15.34) | 19 (21.11) | 0.31 | 0.42 |
| Peak of creatinine, median (IQR)anitha N = 401 | 126 (84–280) | 123 (86–300) | 106 (75–232) | 183 (108–390) | <0.001 | 0.14 |
| Acute cardiac injury, n (%) | 31 (7.5) | 5 (3.33) | 14 (7.95) | 12 (13.33) | 0.016 | 0.25 |
| Need for inotropes, n (%) | 30 (7.2) | 11 (7.33) | 8 (4.55) | 11 (12.22) | 0.07 | 0.81 |
| Pulmonary embolism, n (%) | 59 (14.4) | 30 (20.3) | 17 (9.9) | 12 (13.3) | 0.03 | 0.03 |
| Deep veinous thrombosis, n (%) | 39 (9.6) | 14 (9.5) | 19 (11.1) | 6 (6.7) | 0.51 | >0.99 |
VV-ECMO, venovenous extracorporeal membrane oxygenation; VFD, ventilator-free days; IQR, Inter-quartile range; RRT, Renal replacement therapy.
a
P-value from Kruskal-Wallis, or Chi-square test.
b
Adjusted P-value from the comparison of phenotypes 1 and 2 (Mann-Whitney Wilcoxon or Fisher test) corrected by the Holm method.