Table 2.

Multivariable model in male and female using multivariate Cox survival analysis (backward stepwise, Wald).

variables and subgroups	β	SE	Wald	p-value	HR (95%CI)
Male
diagnostic delay
>10 m					1.0 (Reference)
≤10 m	0.856	0.192	19.885	<0.001	2.353 (1.616, 3.428)
BMI at baseline
>18.70					1.0 (Reference)
≤18.70	0.963	0.231	17.396	<0.001	2.619 (1.666, 4.116)
use of NIPPV
Yes					1.0 (Reference)
No	0.432	0.217	3.955	0.047	1.541 (1.006, 2.360)
ΔALSFRS-R
≤0.63					1.0 (Reference)
>0.63	1.437	0.208	47.688	<0.001	4.208 (2.799, 6.326)
Uric acid at baseline
>292 μmol/L					1.0 (Reference)
≤292 μmol/L	0.661	0.19	12.098	0.001	1.936 (1.334, 2.810)
Female
age of onset
≤55 y					1.0 (Reference)
>55 y	0.74	0.246	9.05	0.003	2.096 (1.294, 3.395)
diagnostic delay
>10 m					1.0 (Reference)
≤10 m	0.873	0.242	12.963	<0.001	2.393 (1.488, 3.848)
BMI at baseline
>18.70					1.0 (Reference)
≤18.70	0.867	0.317	7.486	0.006	2.381 (1.279, 4.431)
ΔALSFRS-R
≤0.63					1.0 (Reference)
>0.63	1.209	0.267	20.529	<0.001	3.351 (1.986, 5.655)

ALSFRS-R, Amyotrophic Lateral Sclerosis Functional Rating Scale–Revised; BMI, body mass index; NIPPV, non-invasive positive pressure ventilation; HR, hazard ratio; CI, confidence interval.