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. 2021 Mar 11;9:656201. doi: 10.3389/fcell.2021.656201

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Copyright © 2021 Zimmermann, Madreiter-Sokolowski, Stryeck and Abdellatif.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Key targets and mechanisms of crosstalk between autophagy and mitochondria. Pharmacological interventions that mainly target autophagy or mitochondrial function are shown in blue and red, respectively. See text for details. Abbreviations: DRP1, Dynamin-1-like protein; eIF5A^Hyp, hypusinated Eukaryotic translation initiation factor 5A-1; ETC, electron transport chain; MFN1/2, Mitofusin-1/2; OPA1, Optic atrophy protein 1/Dynamin-like 120 kDa protein, mitochondrial; PE, phosphatidyethanolamine; PGC-1α, Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; PPARγ, Peroxisome proliferator-activated receptor gamma; ROS, reactive oxygen species; TFEB, Transcription factor EB; ULK1, Unc-51-like kinase 1.