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. 2021 Mar 11;11:625461. doi: 10.3389/fcimb.2021.625461

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Copyright © 2021 Wang, Li, Xiao, Chen, Hu, Li, Guo, Chen, Cai and Tang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Haplotype analyses among TLR2, TLR4, and TLR9 SNPs. The TLR9 (chromosome 3), TLR4 (chromosome 9), and TLR2 (chromosome 4) genes cover 4, 10, and 20 kb, respectively. The location of the genotyped SNPs is indicated with vertical lines. Pairwise linkage disequilibrium (LD) (D’) that was observed in the research population (n = 476) is also depicted. The figure shows R² values for pairwise comparison of the different polymorphisms. R² = 0 represents no LD correlation; R² = 1 represents high (maximum) LD correlation. TLR, Toll-like receptor; SNP, single nucleotide polymorphism.