Table 3.
Allele and genotype frequencies of TLR2, TLR4, and TLR9 SNPs in the subjects.
| Gene | SNP ID | Genotype or allele | TM group (n = 200) | Non-TM group (n = 200) | HC group (n = 76) | Missing | χ2 value | P-value | |
|---|---|---|---|---|---|---|---|---|---|
| TLR2 | rs11935252 | Genotype | 0 | 0.54 | 0.97 | ||||
| A/A | 122 (61.0%) | 124 (62.0%) | 44 (57.9%) | ||||||
| G/A | 69 (34.5%) | 67 (33.5%) | 29 (38.2%) | ||||||
| G/G | 9 (4.5%) | 9 (4.5%) | 3 (3.9%) | ||||||
| Allele | 0.204 | 0.90 | |||||||
| A | 313 (78.2%) | 315 (78.7%) | 117 (77.0%) | ||||||
| G | 87 (21.8%) | 85 (21.3%) | 35 (23.0%) | ||||||
| rs11938228 | Genotype | 10 | 1.42 | 0.84 | |||||
| C/C | 68 (34.8%) | 72 (36.9%) | 24 (31.6%) | ||||||
| C/A | 98 (50.3%) | 96 (49.2%) | 43 (56.6%) | ||||||
| A/A | 29 (14.9%) | 27 (13.9%) | 9 (11.8%) | ||||||
| Allele | 0.24 | 0.89 | |||||||
| C | 234 (60.0%) | 240 (61.5%) | 91 (59.9%) | ||||||
| A | 156 (40.0%) | 150 (38.5%) | 61 (40.1%) | ||||||
| rs1339 | Genotype | 0 | 4.30 | 0.37 | |||||
| T/T | 93 (46.5%) | 80 (40.0%) | 34 (44.7%) | ||||||
| T/C | 88 (44.0%) | 91 (45.5%) | 36 (47.4%) | ||||||
| C/C | 19 (9.5%) | 29 (14.5%) | 6 (7.9%) | ||||||
| Allele | 3.40 | 0.18 | |||||||
| T | 274 (68.5%) | 251 (62.8%) | 104 (68.4%) | ||||||
| C | 126 (31.5%) | 149 (37.2%) | 48 (31.6%) | ||||||
| rs3804099 | Genotype | 4 | 3.38 | 0.50 | |||||
| T/T | 106 (53.5%) | 109 (55.0%) | 40 (52.6%) | ||||||
| T/C | 73 (36.9%) | 76 (38.4%) | 33 (43.4%) | ||||||
| C/C | 19 (9.6%) | 13 (6.6%) | 3 (4.0%) | ||||||
| Allele | 0.48 | 0.79 | |||||||
| T | 289 (72.3%) | 294 (74.2%) | 113 (74.3%) | ||||||
| C | 111 (27.7%) | 102 (25.8%) | 39 (25.7%) | ||||||
| rs76112010 | Genotype | 0 | 3.51 | 0.48 | |||||
| G/G | 105 (52.5%) | 100 (50.0%) | 37 (48.7%) | ||||||
| G/A | 80 (40.0%) | 78 (39.0%) | 35 (46.0%) | ||||||
| A/A | 15 (7.5%) | 22 (11.0%) | 4 (5.3%) | ||||||
| Allele | 0.91 | 0.64 | |||||||
| G | 290 (72.5%) | 278 (69.5%) | 109 (71.7%) | ||||||
| A | 110 (27.5%) | 122 (30.5%) | 43 (28.3%) | ||||||
| rs7656411 | Genotype | 12 | 1.98 | 0.74 | |||||
| G/G | 41 (21.1%) | 40 (20.6%) | 15 (20.0%) | ||||||
| G/T | 99 (51.1%) | 91 (46.9%) | 41 (54.7%) | ||||||
| T/T | 54 (27.8%) | 63 (32.5%) | 19 (25.3%) | ||||||
| Allele | |||||||||
| G | 181 (46.6%) | 171 (44.1%) | 71 (47.3%) | ||||||
| T | 207 (53.4%) | 217 (55.9%) | 79 (52.7%) | ||||||
| TLR4 | rs11536878 | Genotype | 0 | 0.07 | 0.97 | ||||
| C/C | 157 (78.5%) | 159 (79.5%) | 61 (80.3%) | ||||||
| C/A | 41 (20.5%) | 39 (19.5%) | 15 (19.7%) | ||||||
| A/A | 2 (1.0%) | 2 (1.0%) | 0 (0.0%) | ||||||
| Allele | 0.22 | 0.90 | |||||||
| C | 355 (88.7%) | 357 (89.2%) | 137 (90.1%) | ||||||
| A | 45 (11.3%) | 43 (10.8%) | 15 (9.9%) | ||||||
| rs11536889 | Genotype | 0 | 11.2 | 0.02 | |||||
| C/C | 11 (5.5%) | 18 (9.0%) | 14 (18.4%) | ||||||
| C/G | 87 (43.5%) | 84 (42.0%) | 29 (38.2%) | ||||||
| G/G | 102 (51.0%) | 98 (49.0%) | 33 (43.4%) | ||||||
| Allele | 5.51 | 0.06 | |||||||
| C | 109 (27.2%) | 120 (30.0%) | 57 (37.5%) | ||||||
| G | 291 (72.8%) | 280 (70.0%) | 95 (62.5%) | ||||||
| rs11536891 | Genotype | 0 | 0.81 | 0.67 | |||||
| C/C | 3 (1.5%) | 2 (1.0%) | 0 (0.0%) | ||||||
| C/T | 34 (17.0%) | 28 (14.0%) | 11 (14.5%) | ||||||
| T/T | 163 (81.5%) | 170 (85.0%) | 65 (85.5%) | ||||||
| Allele | 1.50 | 0.47 | |||||||
| C | 40 (10.0%) | 32 (8.0%) | 11 (7.2%) | ||||||
| T | 360 (90.0%) | 368 (92.0%) | 141 (92.8%) | ||||||
| rs1554973 | Genotype | 0 | 3.50 | 0.17 | |||||
| C/C | 4 (2.0%) | 4 (2.0%) | 1 (1.3%) | ||||||
| C/T | 51 (25.5%) | 41 (20.5%) | 12 (15.8%) | ||||||
| T/T | 145 (72.5%) | 155 (77.5%) | 63 (82.9%) | ||||||
| Allele | 3.22 | 0.20 | |||||||
| C | 59 (14.7%) | 49 (12.2%) | 14 (9.2%) | ||||||
| T | 341 (85.3%) | 351 (87.8%) | 138 (90.8%) | ||||||
| rs1927911 | Genotype | 4 | 2.06 | 0.73 | |||||
| A/A | 16 (8.1%) | 18 (9.1%) | 5 (6.6%) | ||||||
| A/G | 89 (44.9%) | 96 (48.5%) | 32 (42.1%) | ||||||
| G/G | 93 (47%) | 84 (42.4%) | 39 (51.3%) | ||||||
| Allele | 1.82 | 0.40 | |||||||
| A | 121 (30.6%) | 132 (33.3%) | 42 (27.6%) | ||||||
| G | 275 (69.4%) | 264 (66.7%) | 110 (72.4%) | ||||||
| rs7856729 | Genotype | 0 | 1.09 | 0.58 | |||||
| G/G | 162 (81.0%) | 170 (85.0%) | 65 (85.5%) | ||||||
| G/T | 35 (17.5%) | 28 (14.0%) | 11 (14.5%) | ||||||
| T/T | 3 (1.5%) | 2 (1.0%) | 0 (0.0%) | ||||||
| Allele | 1.83 | 0.40 | |||||||
| G | 359 (89.7%) | 368 (92.0%) | 141 (92.8%) | ||||||
| T | 41 (10.3%) | 32 (8.0%) | 11 (7.2%) | ||||||
| TLR9 | rs187084 | Genotype | 2 | 3.62 | 0.46 | ||||
| AA | 74 (37.2%) | 89 (44.7%) | 36 (47.4%) | ||||||
| AG | 99 (49.7%) | 87 (43.7%) | 33 (43.4%) | ||||||
| GG | 26 (13.1%) | 23 (11.6%) | 7 (9.2%) | ||||||
| Allele | 3.06 | 0.22 | |||||||
| A | 247 (62.1%) | 265 (66.6%) | 105 (69.1%) | ||||||
| G | 151 (37.9%) | 133 (33.4%) | 47 (30.9%) | ||||||
| rs352140 | Genotype | 2 | 2.76 | 0.60 | |||||
| CC | 77 (38.7%) | 92 (46.2%) | 35 (46.1%) | ||||||
| CT | 97 (48.7%) | 87 (43.7%) | 33 (43.4%) | ||||||
| TT | 25 (12.6%) | 20 (10.1%) | 8 (10.5%) | ||||||
| Allele | 2.33 | 0.31 | |||||||
| C | 251 (63.2%) | 271 (68.1%) | 103 (67.8%) | ||||||
| T | 147 (36.8%) | 127 (31.9%) | 49 (32.2%) | ||||||
TM group, AIDS patients withTalaromycosis; Non-TM group, AIDS patients without talaromycosis; HC group, healthy controls group; Missing, genotyping failure; TLR, Toll-like receptor; SNP, single nucleotide polymorphism.
In bold: P value less than 0.05 and is regarded as statistically significant.