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. 2021 Mar 11;11:595609. doi: 10.3389/fonc.2021.595609

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Copyright © 2021 Yang, Jia, Wang, Yang, Du, Luo, Li and Zhu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CircCHST15 regulated PD-L1 expression in lung cancer cells and it was positively correlated to the expression of PD-L1. (A, B) The transfection efficiencies of CircCHST15 and shCircCHST15 in H1395 (A) and A549 (B) cells were determined by RT-qPCR, GAPDH was used as an internal control. (C, F) The gene expressions of PD-L1 in H1395 (C) and A549 (F) cells were determined by RT-qPCR, GAPDH was used as an internal control. (D, E, G, H) The protein expression of PD-L1 in H1395 (D, E) and A549 (G, H) cells was determined by western blot, GAPDH was used as an internal control. (I) The expression of PD-L1 in Ant and lung cancer tissues was determined by RT-qPCR, GAPDH was used as an internal control. (J, K) The correlation between the expressions of CircCHST15 and PD-L1 in Ant (J) and lung cancer tissues (K) was analyzed by Pearson correlation analysis. (^*** P < 0.001, vs. NC; ^{^^^} P < 0.001, vs. shNC). (Ant, adjacent normal tissues).