Table 2.
Application of lncRNAs as a diagnostic index in hepatocellular carcinoma patients.
| LncRNAs | Study sample | Sensitivity (%) | Specificity (%) | References |
|---|---|---|---|---|
| DANCR | HCC vs. LC + CHB | 80.80 | 84.30 | (72) |
| HCC vs. LC + CHB +HC | 80.80 | 84.30 | (72) | |
| LNC NEAT | HCC vs. HC | 100 | 88.90 | (30) |
| MALAT1 | HCC vs. CH +HC | 51.10 | 89.30 | (73) |
| JPX | HCC vs. HC | 100.00 | 52.40 | (74) |
| c-JUN | HCC vs. HC+ CHC | 91.40 | 91.40 | (75) |
| Early HCC vs. HC | 93.10 | 91.40 | (75) | |
| SNHG1 | HBV-HCC vs. LC+ CHB | 70.10 | 68.20 | (76) |
| HBV-HCC vs. HC | 87.30 | 86.00 | (76) | |
| LRB1 | Early HCC vs. HC | 88.38 | 76.79 | (77) |
| SPRY4-IT1 | HCC vs. HC | 87.30 | 50.00 | (78) |
| HBV-HCC vs. LC+ CHB | 43.50 | 86.70 | (78) | |
| ZFAS1 | HCC vs. HC | 55.70 | 90.00 | (79) |
| UCA1 | HCC vs. CHC +HC | 91.40 | 88.60 | (75) |
| Early HCC vs. HC | 93.10 | 88.60 | (75) | |
| LINC00974 | HCC vs. HC | 51.10 | 95.60 | (80) |
| LINC01225 | HCC vs. HC | 76.10 | 44.30 | (81) |
| UCA1 | HCC vs. HC | 92.70 | 82.10 | (82) |
| HCC vs. CHC | 61 | 71 | (82) | |
| WRAP53 | HCC vs. HC | 85.40 | 82.10 | (82) |
| HCC vs. CHC | 85.40 | 71 | (82) | |
| lncRNA-D16366 | HCC vs. HC+CH | 65.50 | 84.60 | (83) |
| LINC00161 | HCC vs. HC | 75.00 | 73.20 | (84) |
| CRNDE | HCC vs. HC | 71.00 | 87.10 | (85) |
| LINC01419 | HCC vs. HC | 48.40 | 96.80 | (85) |
| CRNDE and LINC01419 | HCC vs. HC | 76.70 | 90.30 | (85) |
| LRB1+AFP | Early HCC vs. HC | 82.83 | 81.16 | (77) |
| LRB1+DCP | Early HCC vs. HC | 87.06 | 91.56 | (77) |
| LRB1+AFP+DCP | Early HCC vs. HC | 88.38 | 76.79 | (77) |
| SHNG1 and AFP | HBV-HCC vs. LC+ CHB | 73.40 | 86.10 | (76) |
| HBV-HCC vs. HC | 96.40 | 87 | (76) | |
| SPRY4-IT1 and AFP | HCC vs. HC | 87.30 | 65.00 | (78) |
| JPX + AFP | HCC vs. HC | 97.10 | 72.20 | (74) |
| linc00152, UCA1, and AFP | HCC vs. HC+ LC+ CHB | 82.9 | 88.2 | (86) |
| PVT1 and uc002mbe.2 | HCC vs. HC | 60.56 | 90.62 | (87) |
| AX800134 and uc001ncr | HBV-HCC vs. HC+ CHB | 95.00 | 88.10 | (88) |
| Early HBV-HCC vs. HC+ CHB | 95.70 | 88.10 | (88) | |
| AFP and UCA1 | HCC vs. HC | 100 | 74.20 | (75) |
| UCA1 and c-JUN | HCC vs. HC+ CHC | 97.10 | 80 | (75) |
| Early HCC vs. HC | 100 | 80 | (75) | |
| UCA1 and WRAP53 | HCC vs. HC + CHC | 95.10 | 82.10 | (82) |
| AFP, DCP and MALAT1 | HCC vs. CH +HC | 88.60 | 75.00 | (73) |
| AFP, UCA1, WRAP53 | HCC vs. HC+ CHC | 100 | 62.80 | (82) |
| LOC149086, RP11-160H22.5 and XLOC_014172 | HCC vs. HC | 85.00 | 95.00 | (89) |
| CTBP, LAMP2, miR-16-2 and miR-21 | HCC vs. HC+ CHC | 79.50 | 100 | (90) |
CHC, chronic hepatitis C infection; CHB, chronic HBV hepatitis; HCC, hepatocellular carcinoma; HC, healthy control; CH, chronic hepatitis; HCV-HCC, HCC related with HCV infection; LC, liver cirrhosis; UCA1, Urothelial carcinoma associated-1.