Table 2.
Impact of TCZ on the clinical status of patients (day 0—before TCZ infusion and day 1 to day 7—after TCZ infusion)
| Characteristics | Day 0 | Day 1 | Day 3 | Day 5 | Day 7 | Paired t-test Day 0 v/s Day 1 | Paired t-test Day 0 v/s Day 3 |
|---|---|---|---|---|---|---|---|
| Maximum temperature | 100.8°F | 99.32°F | 97.96°F | 97.7°F | 97.6°F | t = 6.324, p<0.001 | t= 8.869, p<0.001 |
| Oxygen saturation at room air (SpO2) | 86% | 89% | 92% | 96% | 98% | t = 13.26, p <0.001 | t = 21.23, p < 0.001 |
| PaO2 at room air | 43.6 | 50.4 | 63 | 75 | 82.4 | t = 12.23, p <0.001 | t = 20.28, p <0.001 |
| P/F ratio | 208 | 240 | 300 | 357 | 392 | t = 13.56, p <0.001 | t = 20.28, p <0.001 |
| FiO2 requiring to maintain SpO2 > 95% | 60% | 48% | 34% | 27% | 22% | t = 14.48, p <0.001 | t = 16.94, p <0.001 |
| IL-6 | 206.7 | 298.4 | 305.9 | 180.9 | 84.5 | t = 13.33, p <0.001 | t = 7.26, p <0.001 |
| Number of patients on oxygen support | 100% | 100% | 85.71% | 50% | 21.43% | ||
| Average CT severity score | 16.16 | - | - | - | 7.08 |
t, value of paired t-test; p values indicate differences between diabetes and non-diabetes patients, p <0.05 was considered statistically significant; PaO2, partial pressure of oxygen in arterial blood sample; P/F ratio, PaO2/FiO2 ratio; CT, computer tomography