Table 3.
Application of antimicrobial use indicators to finfish aquaculture data.
| Metric/Indicator | Value | Considerations |
|---|---|---|
| mg/PCUaverage treatment weight (mg drug/kg biomass) | 20 | =5,000 kg/(100,000 fish * 2.5 kg) |
| mg/PCUtotal slaughter weight (mg drug/kg biomass) | 10 | =5,000 kg/500,000 kg |
| mg/APCUaverage treatment weight (mg drug/kg biomass) | 13.33 | =5,000 kg/(100,000 fish * 2.5 kg * 1.5 years) |
| mg/APCUtotal slaughter weight (mg drug/kg biomass) | 6.67 | =5,000 kg/(500,000 kg * 1.5 years to market kg)* |
| nDDDvetCAflorfenicol | 200,000 | = 5,000 kg/(10 mg/kg/day * 2.5 kg) |
| DCDvetflorfenicol (mg/kg) | 100 | = DDDvetflorfenicol 10 mg/kg * course 10 d |
| nDCDvetflorfenicol (# of treatment courses) | 20,000 | = 5,000 kg/(DCDvetflorfenicol 100 mg/kg * 2.5 kg) |
| UDDAflorfenicol (mg/fish/day) | 10 | =5,000 kg/(50,000 fish * 10 days) |
| UDDAkg florfenicol (mg/kg of fish/day) | 10 | =5,000 kg/(50,000 fish * 1.0 kg * 10 days) |
| nUDDAflorfenicol (# used daily doses) | 500,000 | =50,000 fish * 1 drug * 10 days |
| Treatment frequencytotal population (doses/fish) | 5 | =nUDDA/100,000 fish |
| Treatment frequencytreated population (doses/fish) | 10 | =nUDDA/50,000 fish |
| Treatment incidence (nDDDvetCA per 1,000 ADR) | 0.73 | =nDDDvetCAflorfenicol/(500,000 kg * 1.5 years * 365/1,000 days)** |
*
Total grow-out length mg/APCUtotal slaughter weight–the slaughter weight was multiplied by the average grow-out cycle length to give the life-adjusted slaughter weight.
**
The nDDDvetCA per 1,000 animal days at risk used the APCU for total slaughter weight as the denominator and scaled per 1,000 fish days at risk.
PCU, population correction unit; APCU, adjusted PCU; nDDDvetCA, number of Defined Daily Doses animal for Canadian data; UDDA, Used Daily Doses Animal; UDDAkg, UDDA/kg of animal; ADR, animal days at risk.