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. 2021 Mar 11;15:628880. doi: 10.3389/fnins.2021.628880

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Copyright © 2021 Duan, Liu, Li, Wang, Hu, Zhang, Tan, Jia, Zhang, von Deneen, Zhang, Nie and Cui.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Group effects for global network metrics (AUC, after Bonferroni correction, P < 0.05/7≈0.0071) by using the human Brainnetome Atlas (HBA). Patients with FCAD/FCNAD showed significantly lower γ and σ than those in the HC group. AUC, area under the curve; C_p, clustering coefficient; L_p, shortest path length; γ, normalized clustering coefficient; λ, normalized shortest path length; σ, small-world-ness; E_glob, global efficiency; E_loc, local efficiency; FCAD, functional constipation associated with anxiety/depressive status; FCNAD, functional constipation without anxiety/depressive status; HC, healthy control.