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. 2021 Mar 11;15:628880. doi: 10.3389/fnins.2021.628880

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Copyright © 2021 Duan, Liu, Li, Wang, Hu, Zhang, Tan, Jia, Zhang, von Deneen, Zhang, Nie and Cui.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Group effects on within-module nodal degree (AUC, P_FDR < 0.05) based on human Brainnetome Atlas (HBA). (A) Significant difference in the rACC. (B) Both FCAD and FCNAD had lower within-module nodal degree than HC in the rACC. Images correspond to a 3D depiction of a see-through model of the areas in the brain, with darker colored ones indicating surface location and lighter colored ones indicating locations deeper in the brain. Nodes in pink represent significant group effect in nodal properties. AUC, area under the curve; rACC, rostral anterior cingulate cortex; FCAD, functional constipation associated with anxiety/depressive status; FCNAD, functional constipation without anxiety/depressive status; HC, healthy control; L, left; R, right.