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. 2021 Mar 11;15:628880. doi: 10.3389/fnins.2021.628880

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Copyright © 2021 Duan, Liu, Li, Wang, Hu, Zhang, Tan, Jia, Zhang, von Deneen, Zhang, Nie and Cui.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Spatial distribution of network modules and connectivity between modules. (A) Modular membership of healthy controls; seven modules were identified for the group-averaged functional network. (B) Group effect on inter-module connectivity between salience and sensorimotor networks (AUC, P_FDR < 0.05). Both FCAD and FCNAD had higher inter-module connectivity between salience and sensorimotor networks, which was negatively correlated with SAS in the FCAD group. AUC, area under the curve; SAS, ZUNG self-rating anxiety scale; FCAD, functional constipation associated with anxiety/depressive status; FCNAD, functional constipation without anxiety/depressive status; HC, healthy control; L, left; R, right.