FIGURE 7.
The subnetwork identified by network-based statistics (PNBS < 0.05). (A) Group effects for region-to-region functional connectivity. (B) Network FCs within the SN in FCAD/FCNAD were lower than those in HC, whereas the opposite trend can be observed outside the SN. (C) In the FCAD group, difficulty of defecation was negatively correlated with RSFC of the DMPFC–rACC, and SDS was negatively correlated with RSFC of the PreCen-aINS. In the FCNAD group, abdominal pain had a negative correlation with RSFC of the aINS-rACC. rACC, rostral anterior cingulate cortex; dACC, dorsal anterior cingulate cortex; PreCen, precentral gyrus; aINS, anterior insula; pINS, posterior insula; PostCen, postcentral gyrus; DMPFC, dorsomedial prefrontal cortex; SDS, ZUNG self-rating depressive scale; FCAD, functional constipation associated with anxiety/depressive status; FCNAD, functional constipation without anxiety/depressive status; HC, healthy control; L, left; R, right.