TABLE 1.

Demographic and clinical information of patients with FCAD, FCNAD, and HC subjects.

		HC (N = 43)	FCon (N = 83) (Mean ± SE)		One-way ANOVA		Post hoc
		(Mean ± SE)	FCNAD (N = 42)	FCAD (N = 41)	F	p	a	b	c
Age (years)		38.0698 ± 2.0942	42.7619 ± 2.0774	38.6098 ± 1.8044	1.6503	0.1962	0.0980	0.8491	0.1473
Gender		18M/25F	16M/26F	10M/31F	3.0981	0.2124	0.4473	0.0709	0.1336
Depression (SDS)		37.3953 ± 1.1780	44.7857 ± 1.0710	69.0244 ± 1.4673	167.1536	<0.001	<0.001	<0.001	<0.001
Anxiety (SAS)		33.4884 ± 1.0462	41.3810 ± 1.0421	63.7073 ± 1.5801	158.6270	<0.001	<0.001	<0.001	<0.001
STAI	State anxiety (SAI)	28.3256 ± 1.2325	33.6667 ± 1.5406	57.3415 ± 1.5176	115.0761	<0.001	0.009	<0.001	<0.001
	Trait anxiety (TAI)	30.0465 ± 1.1489	36.3571 ± 1.4301	55.2439 ± 1.2854	102.2930	<0.001	0.001	<0.001	<0.001
Difficulty of defecation (0–100)		N/A	67.9762 ± 3.1373	71.6585 ± 3.6181	N/A	N/A	N/A	N/A	0.3445
Sensation of incomplete evacuation (0–100)		N/A	63.7619 ± 3.9184	65.5366 ± 4.8007	N/A	N/A	N/A	N/A	0.7242
Abdominal distension (0–100)		N/A	44.6429 ± 4.6566	63.5122 ± 4.6608	N/A	N/A	N/A	N/A	<0.001
Abdominal pain (0–100)		N/A	25.7857 ± 3.6878	34.9024 ± 4.6353	N/A	N/A	N/A	N/A	0.0596

a: cross group comparison between functional constipation and healthy controls (FCNAD vs. HC) to examine the effect of constipation. b: cross group comparison between (FCAD vs. HC) to investigate the effects of constipation and anxiety/depressive status. c: cross group comparison between (FCAD vs. FCNAD) to examine the effect of anxiety/depressive status. FCNAD, functional constipation without anxiety/depressive status; FCAD, functional constipation associated with anxiety/depressive status; HC, healthy control; SE, standard error; SDS, ZUNG Self-rating Depressive Scale; SAS, ZUNG Self-rating Anxiety Scale.