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. 2021 Mar 11;9:646326. doi: 10.3389/fcell.2021.646326

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Copyright © 2021 Xu, Ma, Wu and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Potential trafficking routes and working mechanisms of exosomal miRNAs during pregnancy. Placenta-derived exosomal miRNAs may be delivered to maternal or fetal circulation, and affect various cell events in targeting organs. The mother or fetus-derived exosomal miRNAs may also traffic to the placenta to regulate placental development. Note the dashed lines indicate the uncertainty of evidence by far, the blue arrow indicates endocrine manner and the blue arrow head indicates paracrine manner.