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. 2021 Mar 11;9:630712. doi: 10.3389/fcell.2021.630712

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Copyright © 2021 Dong, Han, Meng, Xu, Zheng and Xia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SHP2 mutation in bone marrow microenvironment promotes myeloproliferative neoplasm. PTPN11 mutation induced by Prx1-cre, Nestin-cre, Osterix-cre, and Lepr-cre in mesenchymal stem cells promotes tumorigenicity of hematopoietic stem cells, whereas PTPN11 mutation induced by VE-Cadherin-cre in endothelial cells and Oc-cre in osteoblasts shows no myeloproliferative neoplasm formation-promoting effect.