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. 2021 Mar 11;9:630712. doi: 10.3389/fcell.2021.630712

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Copyright © 2021 Dong, Han, Meng, Xu, Zheng and Xia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The oncogenic role of SHP2 in tumor immune microenvironment. SHP2 binds to the T cell receptor (TCR) and prevents the activation of T cell induced by the signaling transduction among tumor cells, antigen-presenting cells (APCs), and T cells. SHP2 binds to the colony-stimulating factor-1 receptor (CSF-1R) under the stimulation of CSF-1 and then consequently activates Ras/Raf/MEK/Erk signaling and promotes the proliferation of tumor-associated macrophage (TAM), thus boosting the cancer cell survival. SHP2 in T cells inhibits the activation of T cell via blockage of the function of CD28 and STAT1.