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. 2021 Mar 11;9:640972. doi: 10.3389/fcell.2021.640972

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Copyright © 2021 Kauanova, Urazbayev and Vorobjev.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dose-dependent effect appears not evenly for cell lines studied and IC50 estimations impossible for some cultures. Only in few cases, a decrease in cell velocity is monotonic (for HaCaT and A549 cells under treatment by nocodazole, HeLa, and U2OS cells with similar gradual response for Taxol and for 3T3 cells under treatment by vinorelbine).