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. 2021 Mar 11;9:636327. doi: 10.3389/fcell.2021.636327

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Copyright © 2021 She, Zhu, Deng, Kuang, Fang, Zhang, Duan, Ye, Zhang, Liu, Hu and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of dexmedetomidine on mitochondrial fission and mitochondrial functions after sepsis. (A) TEM (transmission electronic microscopy) images to observe mitochondrial morphology of pulmonary venules in septic rats (Bar, 200 nm), n = 8. (B) Confocal images to observe mitochondrial morphology of VECs after sepsis (Bar, 25 μm), n = 50. (C,D) Time-lapse images of mitochondrial morphologic alternation of VECs per 15 s after sepsis by confocal immunostaining (Bar, 20 μm), n = 3. (E) Effects of dexmedetomidine on the ATP of VECs after sepsis, n = 3. (F–H) Representative confocal images of ROS(Bar, 100 μm) and △Ψm (Bar, 25 μm) after sepsis in VECs, n = 3. (I) Effects of dexmedetomidine on the respiratory control ratio in septic rats, n = 3. Sham: sham group; Sep: sepsis group; CT: conventional treatment group; Normal: nomal group; LPS: lps group; Dex: dexmedetomidine group. ^∗∗P < 0.01, as compared with normal group; ^##P < 0.01, as compared with lps group.