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Schematic diagram of dexmedetomidine regulating mitochondrial fission pathways after sepsis. Dexmedetomidine could inhibite actin polymerization of VECs, leading to the decrease of ER-MITO contact sites. Meanwhile, it also down-regulated the phosphorylation of ERK1/2 and Drp1 ser616, leading to the decrease of the mitochondrial translocation of Drp1 after sepsis in VECs.
