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. 2021 Mar 11;12:627819. doi: 10.3389/fendo.2021.627819

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Copyright © 2021 Dijkstra, van den Berg, Weeber, van de Haar, Velds, Kaing, Peters, Eskens, de Groot, Tesselaar and Voest

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histomorphology of GEP-NEC organoid lines and matching original tumor. (A) Phase-contrast photomicrographs of GEP-NEC organoid lines. Scale bar = 100 µm. (B) Immunostainings of synaptophysin, chromogranin and Ki-67 for organoids and original tumor. P7 indicates passage 7. (C) Hematoxylin and eosin (H&E) stained slides of GEP-NEC organoid lines and original tumors. NEC-01013: passage (P) 12; NEC-02002: P20; NEC-02007: P3.