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. 2021 Mar 11;12:627819. doi: 10.3389/fendo.2021.627819

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Copyright © 2021 Dijkstra, van den Berg, Weeber, van de Haar, Velds, Kaing, Peters, Eskens, de Groot, Tesselaar and Voest

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Copy number profiles of GEP-NEC organoids. (A) Copy number profiles of GEP-NEC organoids are generated based on low-coverage whole genome sequencing and represented on a log₂ scale. NEC-01013: passage (P) 11; NEC-02002: P5. (B) Copy number profiles were based on SNPs identified by whole exome sequencing and analyzed by Sequenza. Allele frequencies are given as ratios and used to infer copy number. NEC-01013: P11; NEC-02002: P15.