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. 2021 Mar 11;12:627819. doi: 10.3389/fendo.2021.627819

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Copyright © 2021 Dijkstra, van den Berg, Weeber, van de Haar, Velds, Kaing, Peters, Eskens, de Groot, Tesselaar and Voest

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Drug response of GEP-NEC organoids. (A, B) Viability (A) or growth-rate corrected viability (B) of cisplatin-treated GEP-NEC organoids. n = 3–4. NEC-01010: passage (P) 6-14; NEC-01013: P10-19; NEC-02002: P6-16. (C, D) Viability (C) or growth-rate corrected viability (D) of everolimus-treated GEP-NEC organoids. n = 3–5. NEC-01010: P6-16; NEC-01013: P10-20; NEC-02002: P6-17. (E) GR at 25 nM everolimus (corresponding to C_max). n = 3–5. Error bars represent s.e.m. Student’s t test. *P < 0.05; **P < 0.01.